Only one of the top four seeds has advanced to the 2026 U.S. World No. 2 and top-seeded Alexander Zverev will take on unseeded Karen Khachanov in Friday's first match, followed by No. 11 Frances Tiafoe facing off against No. 8 seed Ben Shelton. Zverev is looking to win his second Grand Slam event this year, after winning the French Open in June.
He placed second at Wimbledon in July. Khachanov, Tiafoe and Ben Shelton are all seeking a spot in a Grand Slam final for the first time. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: The semis will start with Zverev vs.
ET from Arthur Ashe Stadium in Queens, N.Y. Zverev is the -450 favorite (risk $450 to win $100) to defeat Khachanov (+340) in the latest U.S. The over/under for total games is 38.5 at betting sites.
Meanwhile, Shelton is the -310 favorite over Tiafoe (+245), with that match's total games O/U at 39.5. Before making any 2026 U.S. Open picks, you need to see who proven SportsLine tennis handicapper Jose Onorato is backing.
Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the U.S., he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world's top-ranked doubles players. Onorato has gone 168-106-8 (+107.12 units) on his best bets since 2022.
He correctly called Jannik Sinner in the 2025 Australian Open (+160), Carlos Alcaraz (+130) in the 2025 French Open and Sinner again at 2025 Wimbledon (+180). He also called Coco Gauff (+700) in the 2025 French Open, Iga Swiatek (+1200) at 2025 Wimbledon and then nailed Alexander Zverev (+700) at this year's French Open. Anybody following his tennis picks at sportsbooks and on tennis betting sites could have seen strong returns.
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