Week 1 of college football has finally arrived, and football fans across the country will be treated to several star-studded showdowns, including Auburn vs. LSU opened the 2025 season with a 17-10 victory on the road at Clemson, and now Lane Kiffin will look to start his tenure in Baton Rouge with a convincing victory in front of the home fans at Death Valley. LSU is a 10.5-point favorite against Clemson, according to the latest college football odds at some of the top betting sites like DraftKings Sportsbook.
SportsLine's model is backing LSU to cover the spread in 55% of simulations on Saturday, projecting a double-digit victory for the Tigers. Claim the latest DraftKings promo code, where new users get $200 in bonus bets after making a $5 wager: The model is also backing Cal (+1.5) to cover the spread against UCLA, while the Under (51.5) hits 54% of the time in Boise State vs. Other notable Week 1 college football betting lines include Alabama vs.
East Carolina (+28.5), Baylor vs. Auburn (-7.5), Texas State vs. Texas (-30.5) and Western Michigan vs.
Before locking in your Week 1 college football picks, be sure to check out the top college football betting picks from SportsLine's advanced computer model. Bet on college football with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets: The model simulates every FBS game 10,000 times. It is on a 32-19 run on top-rated college football money-line picks since the 2024 season.
It has also been upgraded for the 2026 season to even better factor in the transfer portal to help nail college football betting picks at sportsbooks and on betting sites. Claim $365 in bonus bets with a $10 bet by signing up for bet365 Sportsbook here: Combining the model's three picks into a Week 1 college football parlay would result in a payout of +585 (risk $100 to win $585). Bet it now at FanDuel Sportsbook and get up to $350 in bonus bets: LSU enters the 2026 season with lofty expectations following Lane Kiffin's arrival in Baton Rouge.
Kiffin compiled a 55–19 (.743 winning percentage) record at Ole Miss during his six-year tenure from 2020 to 2025. Kiffin signed a number of high-profile players in the transfer portal, including quarterback Sam Leavitt, running back Dilin Jones and wide receiver Jayce Brown. Meanwhile, Clemson is coming off its worst season since Dabo Swinney's second year with the Tigers, finishing 7-6 and 4-4 in the ACC.
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