As the 2026 NFL season approaches, bettors will race to sportsbooks to make NFL predictions on the spread, in addition to bets on the money line, total or with player props. However, another wager one could make is a Week 1 NFL score prediction, where you guess what the exact score will be for a given game. This is a high-risk, high-reward NFL bet but one that could produce a massive payout.
Hitting on the exact score for the Chiefs vs. Broncos contest on Monday night could have a return of anywhere from +6000 to +15000. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Looking at previous matchups and the score history could help with making these Week 1 NFL bets.
But even those well-versed with wagering on traditional football predictions could utilize some NFL betting advice with an exact score. Before making any Week 1 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen. A SportsLine expert and host, Cohen is evaluating the entire Week 1 NFL slate and delivers score predictions and logic for each matchup.
He finished the 2025-26 season with a 188-96-1 straight-up record (66%) with his picks at NFL betting sites. Anyone who followed Cohen's NFL predictions on betting sites could have seen strong returns. Now, Cohen has analyzed the latest NFL odds and made his Week 1 NFL picks.
You can only see Cohen's Week 1 NFL exact score predictions at SportsLine. Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: After diving into all 16 games from the NFL Week 1 schedule, Cohen recommends backing the Texans (+1.5 44.5) to defeat Buffalo at the best betting apps. Week 1 road games have been Josh Allen's Kryptonite as over three away starts, he has 10 turnovers, compared to just five passing touchdowns.
None of those previous defenses he faced were as good as this Texans one as they sacked him eight times, and notched two picks, versus Allen and the Bills last year. Also, Cohen points out the notable scoring trends of this matchup. "Houston has won 4 of the last 5 meetings against Josh Allen and Buffalo, each by a single possession.
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