NBA Opening Week continues on Thursday as the Cleveland Cavaliers make their season debut with a visit to the Philadelphia 76ers. The Sixers (1-0) went 45-37 last year and won their season opener on Tuesday, 106-100, spoiling the Knicks' ring and banner night as LeBron James made his team debut. Now, James will face one of his former teams, and it's a Cavs squad coming off a 52-30 record before getting swept in the Eastern Conference Finals by New York.
Visit our Kalshi promo code review and get a $55 trading bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Tipoff is at 7 p.m. ET from Xfinity Mobile Arena in Philadelphia. The Cavs won all four regular season matchups a year ago.
The Sixers are 3.5-point favorites in the latest Cavaliers vs. 76ers odds, while the over/under is 235.5. Before making any 76ers vs. Cavaliers picks, check out the Cavs vs.
Sixers predictions from the SportsLine Projection Model. The SportsLine Projection Model simulates every NBA game 10,000 times and has returned nearly $19,000 in profit for $100 players on its top-rated NBA picks since 2018, including five straight seasons of four-digit profit. The model enters the 2026-27 season off yet another huge season, including going 26-10 (72%) on top-rated spread picks at NBA betting sites.
Anyone following on betting sites could have seen huge returns. Now, the model has simulated Cavaliers vs. 76ers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks.
Here are several NBA odds and betting lines for 76ers vs. Cavaliers: Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 deposit: After 10,000 simulations of Cavs vs. 76ers, SportsLine's model is going Under on the total (235.5) on the best betting apps. Their final two meetings last season both went under, and then the Sixers failed to reach the total in their season-opening win over New York.
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