New therapeutic targets beyond amyloid-β will probably be needed to generate better therapeutic outcomes for patients with Alzheimer’s disease (AD). The transmembrane receptor TREM2 is emerging as one such target; it regulates key functions of microglia, enabling them to respond to pathological cues (including aggregated proteins). Previous efforts to activate TREM2 focused on antibody-based approaches to stabilize the membrane-bound protein, but several factors, including limited brain penetration, limited their utility — and early clinical studies failed to show benefits.
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Shanghai, Beijing, Pune, New Delhi, Berlin or Madrid (hybrid) We are seeking distinguished scholars who will teach at UCAS while conducting research at CAS institute platforms—focusing first on over 20 key areas. University of Chinese Academy of Sciences (UCAS)
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