Lost in the heavyweight fight between the Seahawks and Rams in the NFC West was an excellent rebound 2025 season for the 49ers after going 6-11 the previous year. The return to respectability for the defense led to San Francisco winning at least 12 games for the third time in the last four years. But their season ended in the divisional round from the opening kickoff of their game against the Seahawks, and they'll enter 2026 with a perceived gap between the 49ers and the top two teams in the NFC West.
We're taking a look at everything you need to know before making San Francisco 49ers futures bets below, including odds, trends, 2026 schedule, offseason changes and more before sharing our preseason betting strategy for the team. Fans interested in betting on NFL and Super Bowl futures should check out the latest DraftKings promo code. The Rams trading for Myles Garrett caused a small adjustment in the odds to win the division, conference and Super Bowl for the 49ers, with those prices at +260, +900 and +1700, respectively, prior to the trade on June 1.
The trade did not affect the team's win total initially, but the standard number dropped to 9.5 during June. Expectations have remained high for the 49ers after going to the NFC Championship Game four times in a five year span from 2019-23, though the path back is complicated by playing in the same division as the Seahawks and Rams. Last year's +66 point differential was similar to the 2021 version of the team that went 10-7 then lost the NFC title game to the Rams by three points.
If you want to wager on NFL futures, you have to check out the latest FanDuel promo code. Even though the scoring defense rebounded last year for the 49ers, the unit was below average against both the pass and the run on a per play basis. The defense's interception rate was better than only a Jets squad that didn't register a pick the entire season, while San Francisco's sack rate was worst in the league.
That could be a warning sign if their No. 4 ranking in goal to go situations regresses in 2026, though hopefully better health will lead to improvement for the unit. The offense ranked eighth in yards per pass play but just 30th in yards per rush, and it was the best unit in the league on third downs. The revolving door continues at defensive coordinator with the fifth different coach running the show in a five-year span as Raheem Morris takes over for Robert Saleh.
The defense will see the return of Dre Greenlaw at linebacker, with Osa Odighizuwa coming on board via a trade with the Cowboys to fortify the defensive line. The unit will need Nick Bosa and Mykel Williams to stay healthy this year with the loss of depth at the edge rusher position. On offense, receiver has been the key focus, with Mike Evans and Christian Kirk signed with the 49ers used their first pick on the position as well.
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