The Arizona Cardinals had some sleeper buzz heading into 2025 off the back of a solid season and a busy offseason. But they were quickly left behind in the NFC West and wound up with their worst record since the merger. As a result, the team is rebooting at head coach and quarterback, with Mike LaFleur taking over after three successful seasons as offensive coordinator of the Rams and former No. 1 overall pick Kyler Murray now in Minnesota.
This figures to be a bridge season to the team's next franchise quarterback and, in perhaps the toughest division in football, the Cardinals are the favorite to win the fewest games in the league in 2026. We're taking a look at everything you need to know before making Arizona Cardinals futures bets below, including odds, trends, 2026 schedule, offseason changes and more before sharing our preseason betting strategy for the team. Fans interested in betting on NFL and Super Bowl futures should check out the latest DraftKings promo code.
The Cardinals' win total saw a slight dip after the Rams traded for Myles Garrett on June 1, with Arizona listed at Under 4.5 (-150) before the trade but -170 on that number after the trade, putting their standard win total down to 3.5 with juice on the Over. Their odds to win the NFC West also dropped from +9000 to +10000. The Cardinals are coming off their worst season since going 3-13 in 2018 with by far the worst scoring offense in football the year prior to Murray's arrival.
That team finished -200 in point differential versus -133 for the 2025 Cardinals, a team that only got five starts from Murray and saw the defense finish 29th in scoring. If you want to wager on NFL futures, you have to check out the latest FanDuel promo code. As alluded to above, the Cardinals weren't nearly as bad as their record suggests, with their first five losses all by four points or fewer.
The offense ranked 16th in yards per rush and ninth in third-down success rate, though the passing attack finished 26th in yards per play. While the defense finished 24th in yards per rush and pass play, it had trouble getting off the field, giving up the most first downs per game in the league. With Murray gone, journeyman Gardner Minshew and third-round pick Carson Beck join the mix at quarterback to back up with Jacoby Brissett, but the biggest addition to the unit came on draft day when Arizona used the No. 3 pick to add Jeremiyah Love to the mix at running back, a controversial selection for a team with so many needs.
Nick Rallis remains at defensive coordinator despite the regime change, and he'll have to manage the losses of Jalen Thompson, Dalvin Tomlinson and Calais Campbell, among others. Only two Day 3 picks were used on the defensive side of the ball. Before you wager on NFL or Super Bowl futures, head over to our BetMGM promo code to see a great offer.
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