Lions on Thursday Night Football, as two teams tied for the best record in the NFL since 2023 meet in primetime. Buffalo is a 4.5-point favorite in the latest Bills vs. Lions odds, while the over/under for total points scored is 54.5.
This is the first meeting between these teams since Buffalo recorded a 48-42 win in 2024. Claim the Kalshi promo code CBSSPORTS here now and get a $25 bonus after $25 in trades: Kickoff for Bills vs. Lions is set for 8:15 p.m.
ET at Highmark Stadium in Orchard Park, New York. SportsLine's team of NFL experts have analyzed Bills vs. Lions and revealed their two best bets, and you can also read our NFL betting preview for Thursday Night Football.
Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Week 2 starts off with a thrilling matchup, as the Bills and Lions are tied with the Eagles for the best record in the NFL since 2023 (37-15). Buffalo has won five straight head-to-head meetings between these teams, including a 48-42 win in 2024. Bills quarterback Josh Allen accounted for 430 total yards and four total touchdowns in that game, while Lions quarterback Jared Goff had 494 passing yards and five passing touchdowns.
Detroit is 14-3 in primetime games over the past five seasons, and it is coming off a 31-30 overtime win against the Saints in Week 1. Buffalo is 18-2 in its last 20 home games, and it notched a 36-31 road win over the Texans last week. The Bills are 4.5-point favorites in the Bills vs.
Lions odds, while the over/under is 54.5. Claim $200 in bonus bets after your first $5 wager at DraftKings here: "These two teams both scored and allowed 30 points in Week 1, though it took OT for Detroit. Even taking out overtime, the Lions were torched by Tyler Shough, who finished with 410 yards," SportsLine expert R.J.
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