The Buffalo Bills and coach Joe Brady make their Highmark Stadium regular-season debut when they battle the NFC North-contending Detroit Lions on 'Thursday Night Football' to get the Week 2 NFL schedule underway. The Bills opened the season with an impressive 36-31 win over the Houston Texans in Week 1, while the Lions held off the New Orleans Saints 31-30 in overtime. Detroit (1-0), which finished fourth in the NFC North, was 9-8 in 2025.
Buffalo (1-0), which was second in the AFC East, went 12-5. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Kickoff is set for 8:15 p.m. Bills odds have Buffalo as 4.5-point favorites, while the over/under for total points scored is 53.5.
Before making any Lions vs. Bills picks or 2026 NFL Week 2 predictions, be sure to see what the SportsLine projection model has to say. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model enters Week 2 of the 2026 NFL season on a 53-39 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Now, the model has zoned in on Lions vs.
You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Bills vs. Lions: New to sports trading?
Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: After 10,000 simulations of Lions vs. Bills, the model is going Over 53.5 points at betting apps. Both teams had no problem putting up points in Week 1.
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