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College football odds, lines, schedule for Week 10: No. 1 Miami opens as road underdog at Notre Dame

College football odds, lines, schedule for Week 10: No. 1 Miami opens as road underdog at Notre Dame

cbssports.com 01.11.2026 17:50 9 views
Oddsmsakers have dropped the opening lines for a loaded Week 10 slate

With Week 9 in the books, can we all admit that everyone was looking ahead to Week 10 just a little bit? That's because this weekend features one of the most highly-anticipated slate of games with one marquee matchup after another all day, and the oddsmakers have dropped opening lines for each game. No. 15 LSU and No. 10 Alabama meet in Baton Rouge, Louisiana, in what could be a College Football Playoff elimination game.

The Crimson Tide have owned the Tigers in Death Valley recently, but Keelon Russell struggled mightily in his last game. Despite that home-field advantage, LSU is only a slight favorite as both teams look to avoid a third loss. The primetime matchup with No. 5 Notre Dame hosting top-ranked Miami is one of the top games of the season.

Both teams have shown some vulnerability lately with the Fighting Irish losing to BYU and the Hurricanes narrowly escaping Florida State and North Carolina. Notre Dame opened as a small 4.5-point favorite, at least in part due to the setting, but also because the Miami secondary just got exposed by the Tar Heels in its 38-35 victory Saturday. Elsewhere on a loaded slate, No. 2 Ohio State is a two-score favorite against Oregon, No. 6 Utah is favored over No. 8 BYU in the Holy War and No. 12 Ole Miss is a home underdog against No. 3 Georgia.

Check out the opening lines for all of Week 10's biggest games below. No. 8 BYU at No. 6 Utah (-4.5): Set your alarms because the Holy War kicks off at 10 a.m. local time this year. This matchup is one of the most highly-anticipated ever with both teams eying a Big 12 championship and a spot in the College Football Playoff.

BYU hasn't been at its best since beating Notre Dame a few weeks ago, and Utah has only gotten stronger. That may not bode well for the Cougars, but they also own a three-game winning streak in this series, and we saw that they were capable of at their peak against the Fighting Irish. No. 11 Texas (-3.5) at No. 23 Missouri: Have the Longhorns finally started to hit their stride?

They've conquered the state of Mississippi over the last couple weeks, but a different kind of test awaits Saturday. Texas will take its show on the road to Columbia where it will face a dangerous Missouri team. The Tigers have an explosive passing game led by quarterback Austin Simmons, but their running game just got reinforced as Ahmad Hardy has returned from a gunshot wound he suffered in the offseason.

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