Big Ten ranked matchups highlight the games to make Week 2 college football picks on, as these contests could also serve as CFP previews. Texas has the No. 5 Longhorns as 1.5-point home favorites over the top-ranked Buckeyes, per the Week 2 college football odds. Additionally, these two programs' bitter rivals will face off as well as Michigan vs.
Oklahoma takes place at The Big House, with the Sooners as 5.5-point road favorites. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Elsewhere on the Week 2 college football schedule are several in-state matchups such as LSU vs. Louisiana Tech (+35.5), Penn State vs.
Temple (+24.5) and the Cy-Hawk Trophy being up for grabs in Iowa vs. Before locking in any Week 2 college football picks, be sure to see the latest college football predictions from SportsLine's proven model. The model simulates every FBS game 10,000 times.
It is on a 33-20 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its college football betting picks could have seen strong returns. Now, it has turned its attention to the latest college football odds for Week 2 and locked in picks for every FBS matchup.
Head here to see every pick. Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: One of the top Week 2 college football picks the model is recommending for best betting apps: Kentucky (+10.5, 49.5) covers against No. 13 Alabama in a 3:30 p.m. Former Notre Dame quarterback Kenny Minchey impressed for the Cats in his debut versus Youngstown State with 301 passing yards and four passing touchdowns.
It was a nearly flawless performance for Kentucky, which had zero turnovers and allowed no sacks. Meanwhile, Bama did give the ball away and allowed its quarterback to go down in a victory over East Carolina in Week 1. Kentucky will host Saturday's matchup, and the Wildcats have won three straight home games dating back to 2025 -- including in SEC play -- with all three combing by at least 31 points.
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