The Week 4 college football schedule is when conference play officially kicks off for many teams. The Big Ten features the likes of USC vs. Oregon (-3) and Michigan vs.
Iowa (+4.5) to make Week 4 college football picks on, with the SEC offering Texas vs. Tennessee (-3.5), with Colorado vs. Baylor (-10) over in the Big 12.
Elsewhere, Notre Dame vs. Purdue is always a hotly contested in-state rivalry as the two Battle for the Shillelagh Trophy in their 90th all-time meeting, with the Irish, who are favored by 27.5 points, having won each of the last eight matchups. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Speaking of in-state matchups, Carolinians will look forward to NC State vs.
App State (+14), with the Wolfpack looking to rebound after a shocking last-second defeat to Vanderbilt. Meanwhile, one of the largest Week 4 college football spreads has the Miami Hurricanes favored by 41.5 points over Central Michigan. Before locking in any Week 4 college football picks, be sure to see the latest college football predictions from SportsLine's proven model.
The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks at betting sites so far this season, and it has been upgraded for the 2026 season to better factor in the transfer portal. Anybody following its picks on college football betting sites could have seen strong returns.
Now, it has turned its attention to the latest college football odds for Week 4 and locked in picks for every FBS matchup. Head here to see every pick. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: One of the top Week 4 college football picks the model is recommending for best betting apps: Colorado (+10, 54.5) covers at Baylor in a noon ET kickoff.
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