The Week 5 college football odds aren't showing much love to the 14th-ranked Iowa Hawkeyes. Despite being undefeated and at home, Iowa is a 14-point underdog to No. 5 Ohio State, per the latest college football lines. That's one of three ranked matchups on Saturday, with the others taking place in the SEC.
No. 7 Alabama is favored by 6 points over No. 16 Mississippi State, per the Week 5 college football spreads, while No. 8 Florida is a 4-point road favorite at 25th-ranked Missouri. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Elsewhere, the first leg in the race for the Commander-in-Chief's Trophy takes place during the Week 5 college football schedule. Navy has the Falcons as 2.5-point home favorites.
The biggest spread has the No. 2 Georgia Bulldogs giving 24.5 points to Vanderbilt. Before locking in any Week 5 college football picks, be sure to see the latest college football predictions from SportsLine's proven model. The model simulates every FBS game 10,000 times.
It is on a 32-24 run on all top-rated college football picks at betting sites, returning nearly $600 for $100 players. Anybody following its picks on college football betting sites could have seen strong returns. Now, it has turned its attention to the latest college football odds for Week 5 and locked in picks for every FBS matchup.
Head here to see every pick. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: One of the top Week 5 college football picks the model is recommending for best betting apps: Navy (+2.5, 47.5) covers versus Air Force in a noon ET kickoff. The Falcons will host this contest, which is important to note as Air Force has lost six straight ATS at home versus FBS teams.
Air Force has also lost five straight outright games in the Commander-in-Chief's series, while Navy is on a 4-1 straight-up run as an underdog against unranked squads. With Midshipmen running back Vic Listorti forecasted to rush for nearly 150 yards, Navy covers in over 60% of simulations. Another Week 5 prediction: No. 25 Missouri (+4, 56.5) covers at home versus No. 8 Florida at 3:30 p.m.
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