A couple of undefeated matchups highlight games you can make Week 6 college football best bets on, including an SEC showdown. Alabama has the Tide as 2.5-point home favorites, per the Week 6 college football spreads. That marks a 5-point swing since Georgia opened as 2.5-point favorites.
Elsewhere, the Big Ten boasts Indiana vs. Nebraska (+7.5) as the Hoosiers look to start 6-0 for the third straight season. Get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Other Week 6 college football lines of note include LSU vs.
Kentucky (+8.5), UCLA vs. Oregon (-11.5) on CBS and Paramount+, plus the Red River Rivalry of Texas vs. Oklahoma (+7.5) Oregon will be without star quarterback Dante Moore (concussion).
Before locking in any Week 6 college football picks for those games or others, be sure to see the top Week 6 college football expert picks, predictions and best bets from Thomas Casale. A frequent guest on national radio and TV shows to discuss college sports, Casale has been sports betting -- and winning -- for more than 30 years. He swept all three best bets in his column in both Week 4 and Week 5 on SportsLine and has an 8-1 overall record over the last three weeks.
Now, he has turned his attention to the Week 6 college football odds and is sharing his top picks. If you parlay these college football betting picks on the top sports betting apps, you could be looking at a return of around +600. Get his top college football picks at SportsLine.
Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades: One of Casale's top Week 6 college football picks: He's going Over 58.5 points in UCLA vs. Oregon in a top-25 matchup at 3:30 p.m. After ranking in the top 20 nationally in scoring defense each of the last three years, the Ducks have plummeted to 98th this year.
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