College football is back with its first full weekend of action as the Week 1 schedule unfolds beginning on Thursday. There's at least one FBS matchup every day from Thursday through Labor Day Monday, with a majority of the action coming on Saturday. Baylor are some of the notable matchups that day.
Louisville and Wisconsin vs. Notre Dame are among the Sunday matchups, while SMU vs. Florida State gets a standalone spot on Monday.
Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: The latest Week 1 college football lines have LSU as a 10-point favorite against Clemson, while Ole Miss -7 against Louisville in the only ranked-on-ranked matchup of the week at online betting sites. Before locking in any Week 1college football picks, be sure to see the latest college football score predictions from SportsLine's proven model. The model simulates every FBS game 10,000 times.
It is on a 32-19 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its college football betting picks could have seen strong returns. Now, it has turned its attention to the latest college football odds for Week 1 and locked in picks for every FBS matchup.
Head here to see every pick. Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: One college football score prediction for the Week 1 college football schedule at the best betting apps: The model projects that Penn State beats Marshall 39-11 in Matt Campbell's debut for the Nittany Lions. That makes Penn State (-24.5) the better value against the spread, and the Under the pick for the total, which is at 52.5.
Campbell comes to Happy Valley after an impressive run at Iowa State. He brought a good chunk of that roster with him as well with a couple dozen Cyclones coming to Penn State via the transfer portal, including quarterback Rocco Becht. More than half the roster, in fact, is a product of the portal as many outgoing players followed James Franklin to Virginia Tech or defensive coordinator Jim Knowles to Tennessee.
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