The Cincinnati Reds (63-71) make the trip to Wrigley Field on Friday for a 2:20 p.m. ET matinee against the Chicago Cubs (76-58). Cincinnati won its most recent game, a 10-9 comeback victory over San Francisco on Wednesday, while the Cubs have dropped two of their last three.
Rhett Lowder (5-8, 5.13 ERA) takes the mound for the Reds, while left-hander David Peterson (7-7, 5.17 ERA) starts for Chicago. Chicago holds a 13-game edge over Cincinnati in the NL Central standings this season. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: The Cubs are -188 on the money line (risk $188 to win $100) in the latest Reds vs.
Cubs odds, with the Reds at +168. The over/under for total runs is 8.5. Before making any Reds vs.
Cubs picks, be sure to see the Reds vs. Cubs predictions and betting advice from SportsLine's proven computer model. The SportsLine Projection Model simulates every MLB game 10,000 times and entered Week 23 of the MLB season on a sizzling 49-34 run on all top-rated MLB picks.
It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anyone following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns. Now, the model has set its sights on Reds vs.
Cubs and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Reds vs.
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