TThe Chicago White Sox will look to complete a series sweep over the Cleveland Guardians when they meet in Game 3 of their American League Division Series on Wednesday. Chicago is coming off a 4-3 win over Cleveland on Monday. The Guardians (85-77), who won the AL Central, are 44-37 on the road this season.
The White Sox (84-78), who finished second in the AL Central, are 48-33 on their home field in 2026. Cleveland is expected to start left-hander Foster Griffin (15-6, 3.60 ERA), while right-hander Davis Martin (9-8, 3.95) is expected to start for Chicago. Visit our Kalshi promo code review and get a $55 trading bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: First pitch from Guaranteed Rate Field in Chicago is set for 4 p.m.
Chicago is a -121 favorite on the money line (risk $121 to win $100) in the latest Guardians vs. White Sox odds, while the over/under is 7.5. Before making any White Sox vs.
Guardians picks, be sure to see the Guardians vs. White Sox predictions and betting advice from SportsLine's proven computer model. SportsLine's model simulates every MLB game 10,000 times and enters the divisional round of the 2026 MLB playoffs on a 31-25 run on all top-rated MLB money-line picks at betting sites, returning more than $900 for $100 players.
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You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for White Sox vs. Guardians: Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 deposit: After 10,000 simulations of Guardians vs.
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