Head-fixed intravenous drug self-administration: a new frontier in addiction neuroscience

Drug self-administration studies capture the voluntary, goal-directed nature of human drug taking, allowing investigators to dissociate the behavioral and neural mechanisms that motivate drug seeking and taking from the pharmacological effects of drug exposure itself. Now, a protocol provides instructions for hardware assembly and implementation of intravenous drug self-administration in head-fixed mice. This is a preview of subscription content, access via your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription Receive 12 print issues and online access Prices may be subject to local taxes which are calculated during checkout Spragg, S.

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These authors contributed equally: Kenichiro Negishi, Ginevra D’Ottavio. Behavioral Neuroscience Branch, Intramural Research Program, NIDA-NIH, Baltimore, MD, USA Kenichiro Negishi, Ginevra D’Ottavio & Yavin Shaham The authors declare no competing interests. Negishi, K., D’Ottavio, G. & Shaham, Y.