With jobs on the line, the Detroit Lions face the Indianapolis Colts as the 2026 NFL preseason schedule comes to a close on Saturday. Detroit has split a pair of preseason games and is coming off a 17-13 win over the Washington Commanders. Indianapolis, meanwhile, is still looking for its first win after a 13-13 tie with the New England Patriots in Week 1 and a 34-6 loss to the Atlanta Falcons a week ago.
The Colts are expected to play their starters between eight to 12 snaps as Anthony Richardson starts at quarterback. Visit our DraftKings promo code review to see their latest offers and get started. Claim the latest DraftKings signup promo now: Kickoff is at 1 p.m.
ET from Lucas Oil Stadium in Indianapolis. Colts odds have Indianapolis as 3.5-point favorite, while the over/under for total points scored is 35.5, down a points from the opener. Before making any Lions vs.
Colts picks, be sure to see what Larry Hartstein has to say. A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He enters the 2026 NFL season on a 50-37-1 run on NFL spread picks, a 57.5% win rate.
Anybody following has seen Strong returns! Now, Hartstein has locked in another confident pick for Lions vs. Anybody following his NFL betting picks at sportsbooks and on betting apps could have seen strong returns.
Now, Hartstein has zeroed in on Colts vs. You can head to SportsLine now to see his picks. Here are several NFL odds and betting lines for Lions vs.
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