The 24th-ranked Louisville Cardinals look to rebound from an opening game loss when they take on the Villanova Wildcats in their 2026 home opener on Friday. Louisville is 71-33-3 all-time in home openers, including a 3-0 mark under coach Jeff Brohm. The Wildcats (1-1), who finished second in the Coastal Athletic Association and 12-3 overall in 2025, are coming off a 17-16 win over Bucknell in Week 1.
The Cardinals (0-1), who tied for seventh in the ACC at 4-4 and were 9-4 overall a year ago, dropped a 41-38 decision at Mississippi on Sunday. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is set for 7 p.m. ET from L&N Stadium in Louisville, Ky.
The Cardinals are 36.5-point favorites in the latest Villanova vs. The over/under for total points is 56.5. This will be the first-ever meeting between the teams.
Before making any Villanova vs. Louisville picks, check out what SportsLine college football expert Emory Hunt has to say. Hunt is a CBS Sports HQ analyst who also is featured on SportsLine's Early Edge show breaking down NFL and college football matchups.
He enters this week on a 7-3 roll over his past 10 college football picks on college football betting sites. He has also returned $358 to $100 players on betting sites on top-rated CFB picks. Anyone following could have seen huge returns.
Now, Hunt has locked in another confident pick for Villanova vs. You can visit SportsLine now to see his picks. Here are the FBS college football odds and trends for Louisville vs.
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