Mapping symptom domains and laterality to substantia nigra subregions in early Parkinson’s disease using neuromelanin MRI
Neuromelanin-sensitive MRI (NM-MRI) visualizes the substantia nigra (SN) and aids the diagnosis of Parkinson’s disease (PD), but whether its subregions map onto specific symptoms is unclear. In 105 patients with early PD, the SN was parcellated into ventral (associative), medial (limbic) and dorsolateral (sensorimotor) subregions. Compared with 50 reference participants, volumes were reduced bilaterally in all subregions (all p
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