In a 12-week pilot study, 20 people with early-stage Huntington’s disease restricted their eating to a daily 6–8-h window. The intervention was feasible and well-tolerated, and exploratory analyses suggested improvements in clinical measures, levels of plasma neurofilament light (a biomarker of neurodegeneration) and cellular bioenergetics. This is a preview of subscription content, access via your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription Receive 12 digital issues and online access to articles Prices may be subject to local taxes which are calculated during checkout Wells, R.
Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms. Neurodegener. 13, 17 (2024). A review of preclinical research on time-restricted eating in animal models of HD and a proposed mechanism for its neuroprotective potential.
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The first preclinical evidence that dietary fasting slows disease progression in a mouse model of HD. Article CAS PubMed PubMed Central Google Scholar Parkin, G. Mapping neurodegeneration across the Huntington’s disease spectrum: a five-year longitudinal analysis of plasma neurofilament light. eBioMedicine 104, 105173 (2024).
This study reports the expected annual rise in plasma neurofilament light across HD stages, providing context for the biomarker changes observed here. Bioenergetics in fibroblasts of patients with Huntington disease are associated with age at onset. Significantly lower mitochondrial oxygen consumption was observed in fibroblasts from patients with HD with an earlier age of motor onset independent of CAG repeat size, thus bioenergetic differences may explain part of the variation in HD progression.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This is a summary of: Wells, R. Effects of time-restricted eating in early-stage Huntington’s disease: a pilot study.
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