Primary aldosteronism is one of the most common forms of endocrine hypertension and is associated with increased cardiometabolic risks. Alterations in corticosteroid secretion, including aldosterone, are a characteristic of the disorder, but little is known about the detail of these changes as research has historically relied on blood samples taken at a single timepoint during office hours. A new paper has sought to develop a method to collect more information about how levels of corticosteroids change over the course of a day in these patients.
The authors suggest that using dynamic hormone profiling in this way is a viable system and might offer useful diagnostic information. This is a preview of subscription content, access via your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription Receive 12 print issues and online access Prices may be subject to local taxes which are calculated during checkout Grytaas, M. Tissue corticosteroid rhythms are dysregulated predominantly during sleep in primary aldosteronism.
Med. 18, eaeb7517 (2026) Nature Reviews Endocrinology http://www.nature.com/nrendo/ Greenhill, C. Monitoring corticosteroid levels in primary aldosteronism. Nat Rev Endocrinol (2026). https://doi.org/10.1038/s41574-026-01307-z DOI: https://doi.org/10.1038/s41574-026-01307-z
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