NFC West rivals and Super Bowl contenders clash when the San Francisco 49ers battle the Los Angeles Rams in a season-opening matchup at Melbourne, Australia, on Thursday. Los Angeles and San Francisco tied for second in the division at 12-5 in 2025. The Rams are looking to reach their third Super Bowl in nine seasons, and first since winning Super Bowl LVI during the 2021 season.
The 49ers, meanwhile, are looking to reach their third Super Bowl in eight seasons, and first since losing to Kansas City in Super Bowl LVIII during the 2023 season. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is at 8:35 p.m. ET from Melbourne Cricket Ground.
Rams odds have Los Angeles as a 3.5-point favorite, while the over/under for total points scored is 48.5. Before making any 49ers vs. Rams picks, be sure to see what Micah Roberts has to say.
Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts switched to the other side of the counter and now hands out unique insights in multiple sports. He enters this season on a 19-5 roll on picks involving the 49ers, returning $1,350 to $100 players on NFL betting sites.
Anyone following his picks on betting sites could have seen huge returns. Now, Roberts has zeroed in on 49ers vs. You can head to SportsLine now to see his picks.
Here are several NFL odds and betting lines for Rams vs. 49ers: New to sports trading? Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: Roberts is leaning Over 48.5 combined points for over/under betting at betting apps. The Rams and 49ers had top-10 offenses a year ago.
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