NFL Week 5 odds, predictions, expert picks: Who has edge in Eagles vs. Jaguars in London? Will Texans win?

The 2026 NFL season has been full of surprises up to this point. Who saw the Houston Texans starting 0-4, or the Justin Herbert and Mike McDaniel marriage getting off to this rocky a start? Then, the Cleveland Browns are tied for first in the AFC North with a 3-1 record, while the Minnesota Vikings are a perfect 4-0 despite some concerns on offense.

This week, the Jacksonville Jaguars and Philadelphia Eagles will battle in London. We have an NFC North showdown at Lambeau Field between the Chicago Bears and the Green Bay Packers, the San Francisco 49ers travel to play the rival Seattle Seahawks, and we get an incredible Monday night matchup between the Buffalo Bills and Los Angeles Rams. As we do every week, we've collected all of the best picks and gambling content from CBSSports.com and SportsLine and put them in one place, so you can get sports betting picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, and more.

All NFL betting courtesy of DraftKings Sportsbook. Which picks can you make with confidence this week? And which Super Bowl contender goes down hard?

Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up almost $7,000 for $100 players on top-rated NFL picks since its inception. ET (NFL Network), stream on fubo (try for free) Open: Eagles -1.5, O/U 43.5 "Our London Jaguars fans must feel proud. The team they've supported for years returns to the United Kingdom as arguably the best team in the AFC, and they will take on a squad that looks like it's flailing.

The Eagles blew a 10-point lead to the Los Angeles Rams in the final four minutes of the fourth quarter last Sunday, and went an incredible 0-12 on third downs. If that wasn't bad enough, franchise legend right tackle Lane Johnson decided to retire on Tuesday to focus on his mental health, and the team traded left guard Cam Jurgens to the Baltimore Ravens on Wednesday. I know Jurgens wasn't exactly Larry Allen, but that's just another starter gone on Jalen Hurts' offensive line.

Then, there are the injuries for the Eagles. Running back Saquon Barkley left last week's game with a hamstring injury, and his replacement, Tank Bigsby, was also injured and placed on injured reserve. Star wideout DeVonta Smith missed last week with a hamstring issue as well.