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NFL Week 6 picks, odds: Panthers stun Eagles in Philly, Buccaneers pull off upset

NFL Week 6 picks, odds: Panthers stun Eagles in Philly, Buccaneers pull off upset

cbssports.com 14.10.2026 14:52 6 views
Tyler Sullivan picks every game on the Week 6 schedule, including five locks against the spread

I don't know what it is about the Week 6 slate, but I think we're going to have some underdogs bark rather loudly. I have four underdogs not only finding their way into my five locks of the week, but also two of them pulling off outright upsets. Judging by the headline of this article, you already know that the Panthers are one of those dogs that I think will win in Week 6 as they head up to Philly to face the Eagles.

While I'll get into why I feel that way below, I'm just as fascinated by what may happen if it comes to fruition. Would this be the straw that breaks the camel's back when it comes to Nick Sirianni's job? Or does he live to fight another day and gear up for a do-or-die NFC East showdown in primetime with the Cowboys in Week 7?

Either way, the storylines that could flow out of this upcoming slate feel like they're as juicy as we've seen so far this season, and that's saying something. Anyways, I'll look to improve upon my picks after a lackluster Week 5 where I went 2-3 ATS with my five locks of the week, along with 6-9 ATS and 9-5-1 SU for the overall slate. Note: Cincinnati, Detroit, Miami and Minnesota are on the bye in Week 6.

Carolina comes into this matchup with a pretty sizable rest advantage over Philadelphia. On top of the Panthers coming off of the bye, the Eagles were just in London last week. So, we have one team extremely well rested, while the other is reeling and just came off a demoralizing international loss.

Beyond the lopsided rest advantage, the Eagles just feel like a mess right now. They're bottom five in the league in points per game (18.4), yards per game (262.2), and passing yards per game (170.6) coming into Week 6. Sure, some of that can be attributed to injury, but even when they've had their full squad, it's been clunky.

Conversely, Carolina's offense is top-five in the NFL in those same categories, and it looks like they'll get No. 2 wideout Jalen Coker back for this one. I like the Panthers to roll into Lincoln Financial Field and turn the heat up under Nick Sirianni's seat to a fever pitch. Projected score: Panthers 23, Eagles 21The pick: Panthers +1.5 This is another game that has some outliers worth targeting.

Extract — continue reading at the source.

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