This weekend, two AFC South rivals in the Houston Texans and Jacksonville Jaguars will battle in London, while Caleb Williams looks to return to the lineup against the Atlanta Falcons after missing the last three games. We also have an intriguing matchup in the NFC on Sunday night between the Dallas Cowboys and Green Bay Packers, while the Washington Commanders will look to get back on track against the 49ers in San Francisco following their embarrassing tie with the New York Giants. Dan Quinn needs to find a way to get his team to refocus after they completely forgot about the clock in overtime.
Which teams should you pick in Week 6, and which should you fade? CBS Sports writers Jordan Dajani and Jared Dubin are here to break down the biggest games of the weekend. For clarity, lines for these selections were taken on Oct. 13 over at DraftKings Sportsbook.
Dajani (Seahawks -2.5): Through five weeks, I have only bet against the Denver Broncos once. It's an uncomfortable position to be in, since Bo Nix is "captain comeback." For example, I had zero doubt they would come back from down 16-0 against the Los Angeles Rams in Week 3. Denver has the most comeback wins (15), second-half comebacks (12) and fourth-quarter comebacks (8) in the NFL since 2025.
However, I'm going to fade the Broncos in this spot for a couple of reasons. One, Sean Payton taking back play-calling duties did not help anything against the Los Angeles Chargers. Getting this offense off the ground is, unfortunately, going to take some time — and it probably won't happen against the No. 1 defense in the NFL.
Secondly, the Seahawks have to be mad after that loss to the 49ers. Seattle has won five straight games following a loss, having not lost back-to-back games since 2024. The Seahawks have also won seven straight primetime games, which is the longest active streak in the NFL. … Prediction: Seahawks 23, Broncos 20 Dubin (Seahawks -2.5): Sean Payton's return to calling plays may have resulted in the Broncos coming away with a win, but it did not result in their offense looking competent.
They averaged just 3.9 yards per play against what had previously been a very bad Chargers defense. I cannot rightly expect the Broncos to get anything going against this hellacious Seattle defense. It's not like the Broncos are going to do what the 49ers did.
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