The second-ranked Ohio State Buckeyes will look to stay unbeaten in Big Ten Conference play when they battle the USC Trojans in a key conference battle on Saturday night. Ohio State is coming off a 19-15 win at Indiana on Oct. 17, while USC dropped a 24-7 decision at Wisconsin in Week 8. The Buckeyes (6-1, 4-0 Big Ten), who have won five in a row, are 2-1 on the road this season.
The Trojans (6-2, 3-2 Big Ten), who are seventh in the conference, are 4-1 on their home field in 2026. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 7:30 p.m. ET at the Los Angeles Coliseum.
USC leads the all-time series 13-10-1, but Ohio State earned a 24-7 win in their last meeting at the 2017 Cotton Bowl. The Buckeyes are 6.5-point favorites, with the over/under at 50.5 in the latest Ohio State vs. The total has dropped 5 points since opening at 55.5.
OSU is 5-2 against the spread this season, while Southern Cal is 2-6 versus the line. Before making any USC vs. Ohio State picks, check out the Ohio State vs.
USC predictions from the SportsLine Projection Model. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating Ohio State vs. USC 10,000 times, SportsLine model is going Over 50.5 points at betting apps.
The Over has hit in three of the last five Ohio State games. It has also hit in five of the last nine USC matchups. The Buckeyes are the highest scoring team in the conference, averaging 39.3 points per game.
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