Human brain organoids can provide insights into species-specific mechanisms of neurodevelopment but typically model only early stages of brain formation. Faravelli, Antón-Bolaños and colleagues now show that organoids grown for more than 5 years exhibit molecular signatures of postnatal brain maturation and track the time spent in culture. Using single-cell RNA-sequencing and whole genome methylation profiling, the authors observed cell-type-specific sequences of transcriptional and epigenetic changes in the growing organoids that closely matched those seen in human brain tissue at equivalent developmental stages.
This is a preview of subscription content, access via your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription Receive 12 print issues and online access Prices may be subject to local taxes which are calculated during checkout Faravelli, I. et al. Human brain organoids record the passage of time over multiple years. Nature 657, 713–723 https://doi.org/10.1038/s41586-026-10877-x (2026) Article CAS PubMed PubMed Central Google Scholar Nature Reviews Neuroscience http://www.nature.com/nrn/ Whalley, K.
Old organoids mimic brain maturation. Neurosci. (2026). https://doi.org/10.1038/s41583-026-01086-6 DOI: https://doi.org/10.1038/s41583-026-01086-6
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