The only ranked-on-ranked matchup of the Week 1 college football schedule comes on Sunday evening as the No. 9 Ole Miss Rebels and No. 24 Louisville Cardinals meet in Nashville. Ole Miss made the College Football Playoff last year, but is beginning a new era with Pete Golding in charge for his first full season after he took over in the playoff run last year following Lane Kiffin's exit to LSU. Heisman candidate quarterback Trinidad Chambliss returns, giving Ole Miss a sky-high ceiling this season.
Louisville has been a consistent contender in the ACC under Jeff Brohm as the Cardinals have won at least nine games in all three of his seasons. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is set for 7:30 p.m. ET at Nissan Stadium in Nashville, Tenn.
The Rebels are 6.5-point favorites in the latest Ole Miss vs. Louisville odds, while the over/under is 54.5 points. Before making any Louisville vs.
Ole Miss picks, check out the Louisville vs. Ole Miss predictions from the SportsLine Projection Model. The model simulates every FBS game 10,000 times.
It is on a 32-19 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its college football betting picks could have seen strong returns. Now, the model has set its sights on Louisville vs.
You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Ole Miss vs. Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: After simulated Louisville vs.
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