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Patriots vs. Bills odds, picks, prediction, spread: NFL Week 4 start time, betting preview and best bets

Patriots vs. Bills odds, picks, prediction, spread: NFL Week 4 start time, betting preview and best bets

cbssports.com 04.10.2026 17:15 4 views
Here's everything bettors need to know about the AFC East showdown as the Bills host the Patriots on Sunday at New Highmark Stadium

Quarterback Drake Maye and the New England Patriots need to get something going in NFL Week 4, but it won't be easy to do that Sunday as they visit New Highmark Stadium for an important AFC East battle with the Buffalo Bills. Kickoff is set for 1 p.m. Bills odds at DraftKings Sportsbook list Buffalo as a 7-point favorite, and the Over/Under for total points is set at 49.5.

Bet $5+ on Patriots-Bills in NFL Week 4 with the latest DraftKings promo code and get $150 in bonus bets: We're digging into the Patriots vs. Bills odds at DraftKings Sportsbook, and the SportsLine Projection Model and our NFL experts have crunched the numbers, so we're revealing our best bets here for this AFC East battle. The model simulates every NFL game 10,000 times and is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.

It entered Week 4 of the 2026 NFL season on a 54-43 run on top-rated picks dating to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. The Bills have been cruising, and their new home has been good to them so far.

This is their third straight game at New Highmark, and they have scored 65 points over the first two. They have allowed 47, and the matchup in Houston was a 36-31 shootout, so the defense has some questions, but Allen has had the answers so far. The 30-year-old is angling for a second MVP award after earning it in 2024, as he has 786 passing yards (ninth in NFL), with five TDs and two interceptions.

But he also has 114 yards on the ground and has added six rushing TDs to his NFL record for a quarterback, as he now has 85 for his career. His backfield mate James Cook III is third in the NFL in rushing yards with 346. The Bills' offense ranks fourth in the NFL in both total yards (401.7) and rushing yards per game (155.0).

The passing offense is ninth (246.7), and Allen has spread the ball around. Tight end Dalton Kincaid has been a star, leading the team with 263 receiving yards, and DJ Moore (167) and Keon Coleman (101) are both over 100 receiving yards through three games. Josh Palmer has two catches -- a 43-yard TD and a 34-yard score.

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