The 2026 NFL Kickoff Game will feature the same matchup which closed out last season as the Super Bowl champion Seattle Seahawks host the New England Patriots on Wednesday. Seattle is coming off a 14-3 regular season, which culminated in a 29-13 victory over the Pats in The Big Game. New England also went 14-3 in the regular season in Mike Vrabel's first year as head coach of the team.
New England running back TreVeyon Henderson (ankle) and reserve offensive lineman Ben Brown (knee) are among its inactives. Seattle has some injury questions in the secondary with starting safety Ty Okada (hamstring) out and safety Nick Emmanwori (ankle) both inactive. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is set for 8:20 p.m.
ET from Lumen Field in Seattle. Patriots odds have Seattle as a 3-point favorite. The over/under for total points is at 44.5.
Seattle is -174 on the money line. Before making any Patriots vs. Seahawks picks or 2026 NFL Kickoff Game predictions, be sure to see what the SportsLine projection model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.
Now, the model has zoned in on Seahawks vs. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Patriots vs.
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