NFC West contenders open their regular seasons when the San Francisco 49ers battle the Los Angeles Rams in the 2026 NFL Australia Week 1 matchup in Melbourne on Thursday. Both teams tied for second in the division with 12-5 records last year. The Rams fell short to the eventual champion Seattle Seahawks 31-27 in the NFC Championship Game.
The Niners also were eliminated by the Seahawks, losing 41-6 in a divisional round matchup. Aaron Donald will not play for the Rams this week as he continues to condition following his return from a two-year retirement. Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: Kickoff is at 8:35 p.m.
ET from Melbourne Cricket Ground, where the local time is 10:35 a.m. on Friday morning. The latest Rams vs. 49ers odds have Los Angeles as 3.5-point favorites, while the over/under for total points scored is 48.5. The Over went a combined 23-15-1 for the teams across last year's regular and postseason.
Before making any 49ers vs. Rams picks, be sure to see the NFL Australia game predictions from SportsLine's projection model. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Now, the model has zeroed in on 49ers vs.
You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Rams vs. 49ers: Visit our Polymarket promo code review and get a $50 sign-up bonus as a new user after a $10 deposit here: After 10,000 simulations of 49ers vs. Rams, the model is going Over 48.5 combined points at betting apps.
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