The 2026 NFL schedule kicks off over a four out of six-day stretch when the New England Patriots battle the Seattle Seahawks on Wednesday, Sept. 9. The game will be a rematch from last February's Super Bowl LX matchup, which saw the Seahawks roll to a 29-13 win. The next night, Myles Garrett makes his Rams debut when Los Angeles takes on San Francisco at Melbourne, Australia.
Thirteen games follow on Sunday, including a Sunday Night Football matchup between the Dallas Cowboys and New York Giants as John Harbaugh makes his New York debut as coach. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Week 1 ends with a Monday Night Football matchup between the Denver Broncos and Kansas City Chiefs. Sunday's largest spreads include Cardinals vs.
Chargers (-9.5), Browns vs. Jaguars (-8.5) and Saints vs. The smallest spreads in Week 1 include Bills vs.
Titans (-1.5) and Packers vs. Before making any Week 1 NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI. Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game.
The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines at NFL betting sites, and has hit thousands of 4.5- and 5-star prop picks since the start of the 2023 season. For Week 1, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games.
You can only see the AI predictions for the Week 1 NFL schedule here. Visit our Kalshi promo code review to see their latest offers and get started. Claim the Kalshi signup offer here now: After analyzing every game in Week 1, the AI says the Ravens (-3.5, 47.5), cover comfortably against the Colts on Sunday at 1 p.m.
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