The Pittsburgh Panthers will look to stay perfect on the season when they take on the visiting Syracuse Orange in a standalone ACC matchup on Thursday night. Syracuse is coming off a 21-18 loss to California in Week 2, while Pittsburgh defeated Central Florida 12-7. The Orange (1-1), who tied for 16th in the ACC at 1-7, were 1-4 on the road last season.
The Panthers (2-0), who tied for second in the conference at 6-2, are 6-3 on their home field since the start of 2025. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Kickoff is set for 7:30 p.m. ET at Acrisure Stadium in Pittsburgh.
The Panthers are 10.5-point favorites in the latest Syracuse vs. The over/under for total points is 51.5. Before making any Syracuse vs.
Pittsburgh picks, check out the Syracuse vs. Pittsburgh predictions from the SportsLine Projection Model. The model simulates every FBS game 10,000 times.
It is on a 33-21 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to better factor in the transfer portal. Anybody following its picks on college football betting sites could have seen strong returns. Now, the model has set its sights on Syracuse vs.
You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Pitt vs. Syracuse: New to sports trading?
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