Playoff contenders look to stay perfect on the season when the Detroit Lions battle the Buffalo Bills in a key interconference Week 2 matchup on 'Thursday Night Football' as Buffalo officially opens up its new Highmark Stadium. Detroit is coming off a 31-30 overtime win over the New Orleans Saints, while Buffalo held off the Houston Texans 36-31 on Sunday. The Lions are looking for their fifth consecutive winning season under coach Dan Campbell.
The Bills, meanwhile, are looking to post their eighth winning season in a row and first under coach Joe Brady. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Kickoff is at 8:15 p.m. ET from New Highmark Stadium in Orchard Park, N.Y.
Bills odds have Buffalo as a 4.5-point favorite, while the over/under for total points scored is 54.5, the highest on the Week 2 NFL odds board. Before making any Lions vs. Bills picks, or 'Thursday Night Football' predictions, be sure to see what Larry Hartstein has to say.
A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He is coming off a 2025 NFL season in which he went 50-37 ATS (57.5%), putting him at 643-555 ATS all time. For NFL Office Pool players, Hartstein picked every game straight-up the past two seasons and nailed nearly 70 percent of those picks on NFL betting sites.
He also enters this season on a 22-11-1 roll on his last 34 picks involving the Lions, returning $966 to $100 players. Anyone following his picks on betting sites could have seen huge returns. Now, Hartstein has zeroed in on Lions vs.
You can head to SportsLine now to see his picks. Here are several NFL odds and betting lines for Bills vs. Lions: New to sports trading?
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