Coach Lincoln Riley and the 14th-ranked USC Trojans kick off the 2026 season against the visiting San Jose State Spartans on Saturday. USC, which finished fourth in the Big Ten at 7-2 and were 9-4 overall, is looking to challenge for the conference championship for the first time since joining the Big Ten in 2024. The Trojans return 15 starters -- more than any other team in the nation.
San Jose State, meanwhile, is looking to improve on its 3-9 overall and 2-6 mark in the Mountain West last year. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is set for 3 p.m. ET at Los Angeles Memorial Coliseum.
The Trojans are 38.5-point favorites in the latest USC vs. San Jose State odds, while the over/under is 61.5, marking the widest spread and the highest total on the Week 0 college football odds board. Before making any San Jose State vs.
USC picks, check out the San Jose State vs. USC predictions from the SportsLine Projection Model. The model simulates every FBS game 10,000 times.
It is on a 31-19 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal to help nail college football betting picks at sportsbooks and on betting sites. Now, the model has set its sights on San Jose State vs. You can visit SportsLine now to see the picks.
Here are the FBS college football odds and trends for USC vs. San Jose State: New to sports trading? Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: After simulated San Jose State vs.
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