An NFC West rivalry is set to renew when the San Francisco 49ers take on the Los Angeles Rams on Thursday night. Kickoff from Melbourne, Australia, is set for 8:35 p.m. Kalshi, one of the largest NFL prediction markets, prices the Rams at $0.65 per share to beat the 49ers, who are trading at $0.36 per share.
Rams wide receiver Puka Nacua to record 80+ receiving yards is trading at $0.59 per share. Trade $25 and get a $25 bonus here with the Kalshi promo code CBSSPORTS: The NFL Week 1 schedule also features several other division rivalries, including an NFC North battle between the Green Bay Packers and Minnesota Vikings on Sunday afternoon. Green Bay leads the all-time series 67-61-3, but the Vikings have fared well in recent years, winning six of the past 10 meetings.
The Vikings, who are coming off a 9-8 campaign in 2025, signed former No. 1 overall pick Kyler Murray this offseason to lead the offense. All of the updated Week 1 NFL prediction market prices are listed below, and SportsLine's advanced computer model has all the NFL trading advice and NFL predictions you need to make the best Week 1 NFL picks now. The model entered Week 1 on a 47-32 run on top-rated picks dating back to 2024.
Anybody following its picks on NFL prediction markets and prediction market apps could have seen strong returns. Now, it has turned its attention to the latest Week 1 NFL prediction market prices and locked in predictions for every NFL matchup. Trade on the NFL here with the Polymarket promo code CBSSPORTS and get a $50 bonus after a $10 deposit: Friday's matchup between the Rams and 49ers marks the first-ever NFL game in Australia.
These two teams split the season series in 2025, with both teams securing a win on the road. Rams quarterback Matthew Stafford was electric against San Franaciso last season, throwing seven touchdowns and zero interceptions in two appearances. Stafford is coming off an MVP season, helping the Rams rank first in the NFL in points per game (30.5), total yards per game (394.6), and passing yards per game (268.1).
The 49ers added another offensive weapon in wide receiver Mike Evans this offseason. Evans is coming off an injury-riddled season in Tampa Bay, which snapped his streak of 11 straight seasons with 1,000+ receiving yards. Defensively, the Niners are excited about the return of defensive end Nick Bosa, who's coming back from a torn ACL suffered in Week 3 of 2025.
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