As we saw in Australia to start the year, travel and body clock are things to keep in mind when making NFL picks. The Week 3 NFL schedule is one ripe with contests that could be affected by travel, including a pair of West Coast teams having 1 p.m. ET kickoffs on the East Coast.
The Chargers will visit the Bills, with Buffalo 7-point favorites per the Week 3 NFL odds, while the Seahawks will visit the Commanders, where Seattle is a 6.5-point favorite over a Washington team likely without Jayden Daniels (elbow). Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: But no pair of teams will have to travel quite like Dallas and especially Baltimore. Ravens will take place in Rio de Janeiro, Brazil in the first ever NFL Rio Game.
The Cowboys are the designated home team, but you'll have to back them as 3-point underdogs with your Week 3 NFL bets. All of the updated Week 3 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 3 NFL picks now. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model enters Week 3 of the 2026 NFL season on a 53-41 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Now, it has turned its attention to the latest Week 3 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup.
Head here to see every pick. We can tell you one of the model's strongest Week 3 NFL picks for the best betting apps is that the Lions (-6.5, 47.5) cover versus the Jets in a Sunday 1 p.m. Detroit has a rest advantage in coming off a Thursday loss, but Dan Campbell has shown the ability to get the most out of his players after a defeat.
Detroit is 12-3 ATS following a loss since 2023, with that 80% cover rate the best in the NFL. Campbell should also know the tendencies of Jets HC Aaron Glenn, since the latter coached under Campbell for four years in Detroit. The Jets have played better than expected this year, but they still haven't picked off a pass since 2024 -- a stretch of 19 games -- and they're just 3-6 ATS over their last nine when having less rest than their opponents.
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