Anything can happen in the NFL, and the start to Week 5 of the 2026 season certainly reminded us all of that. The Dallas Cowboys (2-3) entered their "Thursday Night Football" home game against the previously winless Tampa Bay Buccaneers (1-4) as 9.5-point home favorites. Undrafted rookie quarterback Jalon Daniels was making his second career NFL start in place of an injured Baker Mayfield, and the Buccaneers pulled off the third-largest upset win by an undrafted rookie quarterback since the 1970 AFL/NFL merger in a 24-16 victory.
What other craziness could take place across the rest of the NFL's Week 5 slate? Here is a look at five bold predictions. For the first time since their 2006 NFC title season, the Chicago Bears (3-1) are favored at Lambeau Field over the Green Bay Packers (2-2).
This snaps a 19-game streak of visits to Lambeau in which the Bears were the underdog. It makes sense why this has finally shifted. Chicago won two of its three matchups in the 2024 season, including the last two on miraculous comebacks that required rallies from double-digit deficits in both Week 16 and the opening round of the postseason.
This season, the Bears lead the NFL in total offense (429.0 total yards per game), rushing offense (196.3), and first down offense (25.3 first downs per game) despite quarterback Caleb Williams going down midway through Week 2. Even the defense has picked up the slack, allowing the fewest points per game (9.3) in the entire league since Week 2. On the flip side, the Packers' offense is struggling.
They're dead last in rushing yards per game (58.0), nearly 20 yards fewer than the Bengals' 74.3 rushing yards per game. Because of that inability to run the ball with the litany of offensive line injuries they've had, Green Bay's unbalanced offense ranks 28th in scoring (18.3 points per game) and dead last in third down efficiency (26.1% conversion rate. However, the Packers will upset the Bears behind a masterful performance from Jordan Love.
Here's how it will happen. Week 5 is shaping up to be the Green Bay debut of Pro Bowl right guard Kevin Zeitler, whom the Packers signed last week. With Zeitler and new left guard Laken Tomlinson looking down the interior of the pocket, Love will have time to shred the Bears' secondary.
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