The Week 5 NFL schedule has just one game featuring teams over .500 versus one another. Seahawks vs. 49ers has Seattle favored by 3 points at home, per the Week 5 NFL odds, while there's a litany of matchups pitting teams without winning records against each other. Chief among them is Texans vs.
Titans (+6.5) as both squads are winless. Others include Steelers vs. Colts (+2.5) and Bengals vs.
Dolphins (+7) as Miami is, again, the biggest Sunday underdog according to the latest Week 5 NFL lines. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Colts vs. Steelers has a rather slim NFL spread, considering that Indy is coming off a trip from London, while Pittsburgh is coming off a Thursday game and mini-bye.
Speaking of byes, this is the first slate of games with them, and without 16 games to make Week 5 NFL predictions on, you can devote more time, effort and bets on a smaller register of matchups. All of the updated Week 5 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 5 NFL picks now. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Now, it has turned its attention to the latest Week 5 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup.
Head here to see every pick. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades: We can tell you one of the model's strongest Week 5 NFL picks for the best betting apps is that the Vikings (-1.5, 42.5) cover versus the Saints in a Sunday 1 p.m. New Orleans will host, and being a home dog isn't a good thing for Saints backers.
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