The Week 5 NFL schedule has just one game featuring teams over .500 versus one another. Seahawks vs. 49ers has Seattle favored by 3 points at home, per the Week 5 NFL odds, while there's a litany of matchups pitting teams with losing records against each other. Chief among them is Texans vs.
Titans (+7) as both are among the four winless squads left after Tampa won on Thursday versus Dallas. Other matchups include Steelers vs. Cardinals (+5.5) and Bengals vs.
Dolphins (+7) as Miami is, again, among the biggest Sunday underdogs according to the latest Week 5 NFL lines. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: The day ends with an intriguing 'Sunday Night Football' matchup as the surging Falcons (-3) take on the Ravens without Lamar Jackson (ankle). The Falcons have won and covered in two straight, while the Ravens haven't covered since their season opener.
All of the updated Week 5 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 5 NFL picks now. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024.
Anybody following its picks at NFL betting sites could have seen strong returns. Now, it has turned its attention to the latest Week 5 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick.
Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades: We can tell you one of the model's strongest Week 5 NFL picks for the best betting apps is that the Vikings (-2.5, 41.5) cover versus the Saints in a Sunday 1 p.m. New Orleans will host, and being a home dog isn't a good thing for Saints backers. The team is just 1-5 ATS over its last six as a home underdog, and New Orleans coming off a short week won't help.
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