The NLRP3 inflammasome has crucial roles in immunity and disease and is a key target for therapeutic efforts. In this issue of Nature Metabolism, Liu et al. show that l-arginine can inhibit inflammasome activation, highlighting the potential of dietary arginine supplementation as a treatment for NLRP3-related disease. This is a preview of subscription content, access via your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription Receive 12 digital issues and online access to articles Prices may be subject to local taxes which are calculated during checkout Liu, S.
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