The Indianapolis Colts and Washington Commanders will face off Sunday at London's Tottenham Hotspur Stadium at 9:30 a.m. Indianapolis is a 4.5-point favorite in the latest Colts vs. Commanders odds at DraftKings.
Commanders picks should know the total for points is 46.5. Use the best Kalshi promo code CBSSPORTS55 to get a $55 bonus after $25 in trades: We're looking at the latest Colts vs. Commanders odds at DraftKings Sportsbook and sharing insights from the SportsLine Projection Model before we reveal our best bets for the London showdown.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. It entered Week 4 of the 2026 NFL season on a 54-43 run on top-rated picks dating to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.
Washington was expected to hit the skids after losing Daniels to another elbow injury in a 37-20 loss to the Cowboys in Week 2. They had nearly upset the Eagles in the season opener, failing on a two-point conversion that would have tied it with just over a minute left. Daniels went down on the final play before halftime against Dallas as the Commanders looked for a tying touchdown.
The beleaguered quarterback had a team-high 69 rushing yards in the first half. Marcus Mariota took over and is completing almost 64% of his throws for 294 yards and four touchdowns. The Commanders haven't had a ton of success running the ball, with Rachaad White and Jacory Croskey-Merritt combining for 242 rushing yards for the season.
Without Daniels' 100 yards, the Commanders would be averaging less than 100 rushing yards per game. Mariota does have a strong receiving corps to count on, with Terry McLaurin (141 yards, one TD), Stefon Diggs (135 yards, three TDs) and Antonio Williams all capable of keeping the chains moving. Both defenses rank in the bottom six in the NFL, with Washington 27th in yards per game and Indianapolis 32nd.
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