The Week 1 NFL schedule begins with a star-studded showdown on Wednesday, as the New England Patriots travel cross-country to take on the Seattle Seahawks in the 2026 NFL Kickoff Game. Wednesday's matchup is a rematch of Super Bowl LX, a game which Seattle won 29-13. According to the latest NFL betting odds, Seattle is favored by 3.5 points in the season opener, while the over/under is 44.5 points.
You can bet on the NFL Kickoff Game using the latest DraftKings promo code, where new users get $200 in bonus bets after your first $5 wager: Kickoff for Seahawks vs. Patriots is set for 8:20 p.m. SportsLine's team of NFL experts have analyzed Patriots vs.
Seahawks and revealed their three best bets, and you can also read our NFL betting preview for the NFL Kickoff Game. Patriots at FanDuel and get $350 in bonus bets: The Seahawks and Patriots are meeting in a rematch of last season's Super Bowl, marking just the third such rematch in Week 1 of the following season. This is also just the fifth NFL game on a Wednesday since 1950, and the first since there were a pair of games on Christmas in 2024.
Defending Super Bowl champions are 16-5 in NFL Kickoff games since they were introduced in 2004. Seattle returns quarterback Sam Darnold and wide receiver Jaxon Smith-Njigba, while Mike Macdonald is eyeing another strong campaign after becoming the third-youngest head coach to win the Super Bowl. New England is led by MVP runner-up Drake Maye, who became the second-youngest quarterback to start the Super Bowl.
The Seahawks are 3.5-point home favorites in the Seahawks vs. Patriots odds, with the over/under at 44.5. Claim $200 in bonus bets after your first $5 wager at DraftKings here: "I like this spot for AJ Barner who looks like an ascending player for the defending champion Seattle Seahawks," SportsLine expert Alex Selesnick said.
"Barner had a strong rookie season and was a reliable target for Sam Darnold. He dealt with numerous injuries which were addressed in the offseason. New Seahawks OC Brian Fleury, who served as the TE coach in San Francisco for the last four seasons, figures to feature the position more.
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