Recurrent laryngeal nerve (RLN) injury is a rare but serious complication of thyroid surgery and other neck surgery, leading to vocal fold paralysis. The aim of this study was to investigate the therapeutic effects and mechanisms of therapeutic electrical stimulation (TES) on RLN regeneration in a rat model of RLN crush injury. Sprague–Dawley rats were randomly divided into groups of RLN injury and RLN injury + TES, and received RLN injury operation.
The RLN injury + TES group received daily recurrent laryngeal nerve electrical stimulation for 14 days. Functional recovery including vocal fold mobility scoring and electrophysiological measurements was assessed. Structural changes were evaluated using histology and transmission electron microscopy.
In comparison with observation management, TES improved vocal fold mobility(p
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